Is pantoprazole the same as Prilosec? Are Protonix and Prilosec the Same Thing? Protonix (pantoprazole sodium) and Prilosec (omeprazole) are proton pump inhibitors (PPIs) used to treat gastroesophageal reflux disease (GERD) and a history of erosive esophagitis. Prilosec is also used to treat ulcers and frequent heartburn. What over the counter drug is equivalent to pantoprazole? Protonix is available by prescription while Prilosec is available over-the-counter (OTC) and as a generic. Should pantoprazole be taken on an empty stomach? You can take PROTONIX tablets with food or on an empty stomach. Swallow PROTONIX tablets whole. If you have trouble swallowing a PROTONIX 40 mg tablet, you can take two 20 mg tablets instead.
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